The NHS has issued an important warning for people who use common painkillers, advising the public not to mix ibuprofen with other nonsteroidal anti-inflammatory drugs (NSAIDs) such as naproxen or aspirin. Taking these medications together could increase the risk of serious side effects.
Over-the-counter painkillers like ibuprofen are widely used across the UK to relieve headaches, period pain, backache, cold and flu symptoms, joint pain and general inflammation. Ibuprofen, sold under brand names such as Nurofen, Calprofen and Ibuleve, is one of the most commonly purchased medicines that does not require a prescription.
While ibuprofen is considered safe when used correctly, the NHS emphasises that some medication combinations can be harmful — and certain painkillers should never be taken together.
According to NHS guidance, ibuprofen “does not mix well with some medicines,” especially other NSAIDs.This includes:
Taking two NSAIDs at the same time can significantly increase the risk of adverse effects such as:
Mixing NSAIDs greatly increases the chance of complications, including:
The NHS also states that the risk is higher if someone is taking high doses of ibuprofen or using it for a long period of time.
Many cold and flu products contain hidden NSAIDs, meaning someone could accidentally double-dose without realising.
Checking medication labels is essential — especially if you already take ibuprofen regularly or are on long-term treatment.
For personalised advice, you can book a same-day private GP appointment to ensure your medication combinations are safe.
You should speak to a doctor or pharmacist before taking ibuprofen if you:
Mixing medications without professional guidance increases the risk of complications. A private prescription consultation is recommended if you take multiple medicines regularly.
If additional pain relief is needed, the NHS usually advises considering paracetamol instead of another NSAID. However, you should always confirm this with a healthcare professional to ensure it is safe for your individual situation.
If you’re unsure which painkiller is right for you, you can speak with one of our clinicians during a GP Consultation.
If you are unsure about which painkillers are safe to combine — or if you are experiencing stomach pain, dizziness, nausea, swelling or any unusual symptoms after taking ibuprofen, naproxen or aspirin — our clinicians can help.
At Private Medical Clinic, we offer:
Our doctors provide clear, personalised advice to ensure you are taking your medication safely.
Dr. Kishan Dattani (MBBS, MRes) is a dedicated doctor with experience across multiple specialties and a research background in osteoarthritis. Practicing at Private Medical Clinic, he is passionate about delivering high-quality, patient-centred care to the local community.
