Understanding Breast Cancer Recurrence: New Blood Tests, Risk Factors & Recurrence Rates Explained

Woman Smiling Breast Cancer Awareness Portrait

Breast cancer is the most common cancer in women worldwide — and while treatment has come a long way, many patients live with the fear that it could come back. Understanding the risk of recurrence of breast cancer is crucial for peace of mind, early action, and better outcomes.

Recently, a new blood test for breast cancer recurrence has been developed that can detect returning cancer before it shows up on scans. In this blog, we'll look at what this means, who's most at risk, symptoms of recurrence, and how tools like recurrence risk calculators and blood tests can help.

What Is Breast Cancer Recurrence?

Breast cancer recurrence refers to the return of cancer after treatment and after a period of time when it wasn't detectable. It can come back in the same breast or scar tissue (local recurrence), nearby lymph nodes or tissues (regional recurrence), or other parts of the body like the bones, lungs or liver (distant recurrence or metastasis).

Game-Changer: New Blood Tests for Breast Cancer Recurrence

A UK research team at the Institute of Cancer Research in London has developed a highly sensitive blood test for breast cancer recurrence. This test detects small traces of tumour DNA in the blood — even before any signs appear on imaging.

Key Takeaways

  • Tested on 78 women with early-stage breast cancer
  • The blood test accurately predicted recurrence in 100% of those whose cancer returned
  • Cancer was detected months or even years earlier than with standard scans
  • Could lead to earlier treatment and better survival rates

This breakthrough could mean routine blood tests for breast cancer recurrence become a powerful tool for monitoring patients after treatment.

What Type of Breast Cancer Has the Highest Recurrence Rate?

Different types of breast cancer carry different risks of coming back:

Triple-Negative Breast Cancer

  • Higher chance of recurrence in the first 3–5 years
  • Often more aggressive and fast-growing

HER2-Positive Breast Cancer

  • Used to have a high recurrence rate, but targeted therapies (like Herceptin) have improved outcomes

Hormone-Receptor-Positive Breast Cancer (ER+/PR+)

  • Lower short-term risk, but can return even 10–20 years later

Knowing what type of breast cancer has the highest recurrence rate can help guide follow-up plans and lifestyle choices.

What Are the Symptoms of Breast Cancer Recurrence?

If cancer returns, the symptoms may depend on where it comes back.

Local Recurrence

  • New lump in the breast or chest wall
  • Redness or thickening of the skin
  • Nipple changes or discharge

Distant Recurrence (Metastasis)

  • Bone pain
  • Shortness of breath
  • Unexplained weight loss
  • Fatigue or weakness
  • Headaches or neurological symptoms

Always speak to your GP or specialist if you notice breast cancer recurrence symptoms.

Understanding the Risk of Recurrence of Breast Cancer

Your chances of breast cancer recurrence depend on a mix of factors:

  • Type and stage of your original cancer
  • Whether it had spread to lymph nodes
  • Treatments received (surgery, chemo, radiation, hormone therapy)
  • Genetic factors (e.g. BRCA mutation)
  • Lifestyle (smoking, alcohol, obesity, etc.)

A breast cancer recurrence risk calculator can estimate your individual risk — something your specialist or private GP may use as part of your care plan.

What's the Breast Cancer Recurrence Rate?

Overall, the breast cancer recurrence rate varies:

Type of Recurrence Approximate Rate
 Local recurrence  5–10% (after lumpectomy + radiation)
 Distant/metastatic  20–30% (in higher-risk patients)
 Triple-negative cancers  Up to 40% within 5 years

These numbers aren't meant to scare you — they help inform better monitoring, prevention, and personalised follow-up care.

Can You Reduce Your Risk of Recurrence?

Yes — here are a few steps you can take:

Stick to Follow-Up Appointments

Early signs are more treatable — regular reviews with your private GP or oncology team matter.

Consider Routine Blood Tests

Discuss the new breast cancer recurrence blood test with your doctor to see if it's suitable.

Maintain a Healthy Lifestyle

  • Keep a healthy weight
  • Exercise regularly
  • Eat a balanced diet
  • Limit alcohol and quit smoking

Take Prescribed Medications

If you're on hormone therapy (like Tamoxifen), take it consistently for the recommended duration.

When to Speak to a Private GP

If you're concerned about your risk of recurrence, want faster access to scans, or are curious about new blood tests for breast cancer recurrence, a private GP can help with:

  • Personalised risk assessments
  • Referral to specialists
  • Monitoring using blood tests
  • Support for symptoms and anxiety

You can book a confidential consultation with our Private GP for breast cancer recurrence assessment.

FAQs About Breast Cancer Recurrence

What is the first sign of breast cancer coming back?

Often a new lump, pain, or skin changes near the surgery site. In metastatic cases, signs might include fatigue, weight loss, or bone pain.

Can a blood test detect breast cancer returning?

Yes — emerging blood tests for breast cancer recurrence can detect tumour DNA before a scan shows anything. These are still being developed but show great promise.

How likely is breast cancer to return after 5 years?

If cancer hasn't returned in 5 years, your risk decreases — especially for triple-negative and HER2+ cancers. However, hormone-receptor-positive cancers can still return later.

Where is breast cancer most likely to spread?

Common sites are the bones, lungs, liver, and brain.

How much does it cost to see a private GP about breast cancer concerns?

At Private Medical Clinic, we offer fast, flexible access. You can learn more about private GP costs here.

Take Action Today

Breast cancer survivors often carry invisible worry about recurrence. But with new tools like recurrence blood tests, clearer risk calculators, and tailored private GP support — you don't have to face it alone.

If you'd like peace of mind or support with your post-cancer care, book a consultation today via our private GP's or explore our full range of health services.

Dr Teresha Jayawardena

Dr. Teresha Jayawardena (MBChB, MRCGP, MSc, DRCOG) is a private GP with specialist expertise in women's and sexual health. With extensive postgraduate training and experience across multiple medical disciplines, she is dedicated to delivering compassionate, evidence-based care tailored to her patients' needs.

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